| NCT05157282 | Spinal Cord Stimulation for Functional Recovery in Humans With Tetraplegia | VA Office of Research and Development | | - Age 18 - 70 yrs
- Level C1-C8
AIS A, B, C, D, E- ≥ 1 years
- Be a veteran eligible for treatment in the Veterans Administration Healthcare System
- Be able to produce some gripping motion in at least one hand
- Have at least some light touch and pin prick sensation awareness in the C6, C7, and C8 dermatomes of the hand
- Have MRI evidence of cervical spinal cord injury at or above the C8 level
- NOT have uncontrolled medical problems including pulmonary, cardiovascular or orthopedic disease
- NOT have an implanted pacemaker
- NOT have a history of head injury or stroke
- NOT have a history of seizures or drug treatment with medicines that lower seizure threshold
| Recruiting | 86 | NA | Technology | Arm/hand function | - Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
- Motor evoked potential
| 6 months | 25 January 2023 | 14 December 2021 | 2 | |
| NCT05249595 | Ultrasound Imaging Based Sensing of Human Ankle Motion Intent and Control Strategies for Ankle Assistance | North Carolina State University | | - Age 18 - 64 yrs
- Level C1-L5
AIS C, D- ≥ 3 months
- be able to walk over ground independently either with or without an assistive device
- NOT have severe spasticity
- NOT have untreatable chronic pain
- NOT weigh more than 220 lbs
- NOT have severe reduction (greater than 20 degrees) of lower limb range of motion
- NOT be at high risk of fracture due to osteoporosis
| | 25 | NA | Technology | Standing/walking/mobility | - Electromyography
- Surface Electromyography (sEMG)
| Participant completion of study sessions (typically 8 sessions). | 10 February 2020 | 21 February 2022 | 2 | |
| NCT05386537 | Combining Wearable Robotic Orthosis With Visual and Haptic Feedback to Enhance the Recovery of Upper Extremity Motor Function and ADL in Persons With Acute SCI | Kessler Foundation | | - Age 18 - 80 yrs
- Level -
AIS C, D- ≤ 3 months
- Be able to activate the muscles of the upper arm and forearm with enough strength as determined by the therapist.
- Have full passive range of motion of elbow, as determined by study staff
- NOT have excessive spasticity in elbow or wrist jointsas determined by study staff
- NOT have a history of neurologic disorder other than spinal spinal cord injury
- NOT have severe psychiatric problems
- NOT have a history of epilepsy, seizure, or convulsion
| | 20 | EARLY_PHASE1 | Rehabilitation | Arm/hand function | - Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
- Surface Electromyography (sEMG)
| 10 weeks | 01 April 2021 | 23 May 2022 | 1 | |
| NCT05411692 | Functional Electrical Stimulations With and Without Motor Priming Exercises in Spinal Cord Injury | Riphah International University | | - Age 15 - 50 yrs
- Level C6-C7
AIS D- ≤ 18 months
- HAVE voluntary wrist extension
| Ended | 26 | NA | Technology | Arm/hand function | - American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
- Hand-Held Myometery / Dynamometry
- Spinal Cord Independence Measure (SCIM)
| 6 weeks | 15 March 2022 | 09 June 2022 | 1 | |
| NCT05115149 | The Study of a Neural Interface and a Neurostimulation in the Rehabilitation of Upper Limb Movement Impairments. | Skolkovo Institute of Science and Technology | | - Age 18 - 60 yrs
- Level C3-C7
AIS A, B- ≥ 1 months
- NOT have severe cognitive impairments
- NOT have a concomitant disease which has resulted in decrease in muscle strength or increase in muscle tone
- NOT have a significant loss of joint range of motion
- NOT be taking muscle relaxant medication
- NOT have an implanted pacemaker or other implanted electronic device
| | 60 | NA | Technology | Arm/hand function | - Action Research Arm Test (ARAT)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Ashworth and Modified Ashworth Scale (MAS)
- Capabilities of Upper Extremity Instrument (CUE- Q and CUE-T)
- Rivermead Mobility Index (RMI)
- Short Form 36 (SF-36)
- Spinal Cord Independence Measure (SCIM)
| 6 weeks | 01 October 2021 | 10 November 2021 | 12 | |
| NCT05284201 | LIFT Home Study of Non-Invasive ARC Therapy for Spinal Cord Injury | ONWARD Medical, Inc. | | - Age 22 - 75 yrs
- Level C2-C8
AIS B, C, D- ≥ 12 months
- have completed the Up-LIFT Study within the prior 12 months
- be indicated for upper extremity training procedures by treating physician, occupational therapist or physical therapist
| Ended | 17 | NA | Technology | General health | | 6 months | 03 March 2022 | 17 March 2022 | 5 | |
