| NCT05429736 | Activating Spinal Circuits to Improve Walking, Balance, Strength, and Reduce Spasticity | Shepherd Center, Atlanta GA | | - Age 18 - 70 yrs
- Level C1-T12
AIS C, D- ≥ 12 months
- be able to stand for at least 5 minutes (with or without an assistive device)
- be able to move each leg independently for at least three steps
- be able to rise from sit to stand with no more than moderate assistance from one person
| Recruiting | 28 | NA | Technology | Standing/walking/mobility | - 10 Meter Walking Test (10 MWT)
- 2 Minute Walk Test
- Berg Balance Scale (BBS)
- Falls Efficacy Scale (FES, Tinetti)
- Spinal Cord Assessment Tool for Spastic Reflexes (SCATS)
- Spinal Cord Injury Spasticity Evaluation Tool (SCI-SET)
| 27 days | 01 March 2022 | 23 June 2022 | 1 | |
| NCT05255679 | Early FES Cycling in Acute Spinal Cord Injury for Neuromuscular Preservation and Neurorecovery | University of Alberta | | - Age 18 - 80 yrs
- Level C1-L5
AIS A, B, C, D- 14 days - 21 days
- NOT be able to walk without assistive devices
- NOT have contraindications for Transcranial Magnetic Stimulation (TMS)
- NOT have autonomic dysreflexia
- NOT have an implanted stimular or pacemaker
| Ended | 35 | NA | Rehabilitation | Standing/walking/mobility | - 10 Meter Walking Test (10 MWT)
- 6-Minute Walk Test (6MWT)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- European Quality of Life Five Dimension Five Level Scale (EQ-5D-5L)
- Motor evoked potential
- Nerve Conduction Studies (compound motor action potentials - cMAP, sensory action potentials- SNAP, f-wave, H reflex)
- Patient Health Questionnaire-9 (PHQ-9)
- Surface Electromyography (sEMG)
| 6 months | 21 April 2021 | 24 February 2022 | 1 | |
| NCT05111093 | Epidural Electrical Stimulation to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury | Ecole Polytechnique Fédérale de Lausanne | | - Age 18 - 70 yrs
- Level C3-T6
AIS A, B, C, D, E- ≥ 1 months
- have confirmed hypotension
| Recruiting | 20 | NA | Technology | General health | - Ashworth and Modified Ashworth Scale (MAS)
- Spinal Cord Independence Measure (SCIM)
| 26 months | 29 November 2021 | 08 November 2021 | 1 | |
| NCT05163639 | Spinal Cord Associative Plasticity Study | Columbia University | | - Age 18 - 80 yrs
- Level C1-C8
AIS - ≥ 1 years
- NOT have a history of seizures, stroke, brain tumor, brain abscess, or multiple sclerosis
- NOT have a history of moderate or severe head trauma
- NOT have a shistory of implanted brain/spine/nerve stimulators, pacemaker, cochlear implant etc
- NOT have a history of psychiatric disorders
- NOT have epilepsy
| Recruiting | 92 | EARLY_PHASE1 | Technology | Arm/hand function | - Electromyography
- H reflex
- Hand-Held Myometery / Dynamometry
- Nerve Conduction Studies (compound motor action potentials - cMAP, sensory action potentials- SNAP, f-wave, H reflex)
| 1 hour after stimulation is completed | 10 September 2021 | 20 December 2021 | 4 | |
| NCT05191121 | Improving Upper Extremity Function and Trunk Stability After Cervical Spinal Cord Injury (SCI) | Craig Hospital | | - Age ≥ 18 yrs
- Level C1-C8
AIS B, C, D- ≤ 5 months
- Currently receive inpatient rehabilitation at Craig Hospital
- NOT have implanted devices including pacemakers, spinal cord stimulators, intra-thecal pumps, etc.
| By invitation | 99 | NA | Rehabilitation | Arm/hand function | - American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Capabilities of Upper Extremity Instrument (CUE- Q and CUE-T)
- Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
- Hand-Held Myometery / Dynamometry
- Modified Functional Reach Test (mFRT)
| 12 weeks | 23 February 2022 | 13 January 2022 | 1 | |
| NCT05180227 | Transcutaneous Stimulation in Spinal Cord Injury | VA Office of Research and Development | | - Age 21 - 70 yrs
- Level C1-T6
AIS A, B, C- ≥ 1 years
- NOT be ventilator dependent
- NOT have a history of diabetes
| Ended | 10 | NA | Technology | General health | | 2 years | 01 June 2022 | 06 January 2022 | 3 | |
