| NCT05163639 | Spinal Cord Associative Plasticity Study | Columbia University | | - Age 18 - 80 yrs
- Level C1-C8
AIS - ≥ 1 years
- NOT have a history of seizures, stroke, brain tumor, brain abscess, or multiple sclerosis
- NOT have a history of moderate or severe head trauma
- NOT have a shistory of implanted brain/spine/nerve stimulators, pacemaker, cochlear implant etc
- NOT have a history of psychiatric disorders
- NOT have epilepsy
| Recruiting | 92 | EARLY_PHASE1 | Technology | Arm/hand function | - Electromyography
- H reflex
- Hand-Held Myometery / Dynamometry
- Nerve Conduction Studies (compound motor action potentials - cMAP, sensory action potentials- SNAP, f-wave, H reflex)
| 1 hour after stimulation is completed | 10 September 2021 | 20 December 2021 | 4 | |
| NCT05191121 | Improving Upper Extremity Function and Trunk Stability After Cervical Spinal Cord Injury (SCI) | Craig Hospital | | - Age ≥ 18 yrs
- Level C1-C8
AIS B, C, D- ≤ 5 months
- Currently receive inpatient rehabilitation at Craig Hospital
- NOT have implanted devices including pacemakers, spinal cord stimulators, intra-thecal pumps, etc.
| By invitation | 99 | NA | Rehabilitation | Arm/hand function | - American Spinal Injury Association Impairment Scale (AIS)
- Capabilities of Upper Extremity Instrument (CUE- Q and CUE-T)
- Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
- Hand-Held Myometery / Dynamometry
- International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Modified Functional Reach Test (mFRT)
| 12 weeks | 23 February 2022 | 13 January 2022 | 1 | |
| NCT05180227 | Transcutaneous Stimulation in Spinal Cord Injury | VA Office of Research and Development | | - Age 21 - 70 yrs
- Level C1-T6
AIS A, B, C- ≥ 1 years
- NOT be ventilator dependent
- NOT have a history of diabetes
| Ended | 10 | NA | Technology | General health | | 2 years | 01 June 2022 | 06 January 2022 | 3 | |
| NCT05157282 | Spinal Cord Stimulation for Functional Recovery in Humans With Tetraplegia | VA Office of Research and Development | | - Age 18 - 70 yrs
- Level C1-C8
AIS A, B, C, D, E- ≥ 1 years
- Be a veteran eligible for treatment in the Veterans Administration Healthcare System
- Be able to produce some gripping motion in at least one hand
- Have at least some light touch and pin prick sensation awareness in the C6, C7, and C8 dermatomes of the hand
- Have MRI evidence of cervical spinal cord injury at or above the C8 level
- NOT have uncontrolled medical problems including pulmonary, cardiovascular or orthopedic disease
- NOT have an implanted pacemaker
- NOT have a history of head injury or stroke
- NOT have a history of seizures or drug treatment with medicines that lower seizure threshold
| Recruiting | 86 | NA | Technology | Arm/hand function | - Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
- Motor evoked potential
| 6 months | 25 January 2023 | 14 December 2021 | 2 | |
| NCT05249595 | Ultrasound Imaging Based Sensing of Human Ankle Motion Intent and Control Strategies for Ankle Assistance | North Carolina State University | | - Age 18 - 64 yrs
- Level C1-L5
AIS C, D- ≥ 3 months
- be able to walk over ground independently either with or without an assistive device
- NOT have severe spasticity
- NOT have untreatable chronic pain
- NOT weigh more than 220 lbs
- NOT have severe reduction (greater than 20 degrees) of lower limb range of motion
- NOT be at high risk of fracture due to osteoporosis
| | 25 | NA | Technology | Standing/walking/mobility | - Electromyography
- Surface Electromyography (sEMG)
| Participant completion of study sessions (typically 8 sessions). | 10 February 2020 | 21 February 2022 | 2 | |
| NCT05386537 | Combining Wearable Robotic Orthosis With Visual and Haptic Feedback to Enhance the Recovery of Upper Extremity Motor Function and ADL in Persons With Acute SCI | Kessler Foundation | | - Age 18 - 80 yrs
- Level -
AIS C, D- ≤ 3 months
- Be able to activate the muscles of the upper arm and forearm with enough strength as determined by the therapist.
- Have full passive range of motion of elbow, as determined by study staff
- NOT have excessive spasticity in elbow or wrist jointsas determined by study staff
- NOT have a history of neurologic disorder other than spinal spinal cord injury
- NOT have severe psychiatric problems
- NOT have a history of epilepsy, seizure, or convulsion
| | 20 | EARLY_PHASE1 | Rehabilitation | Arm/hand function | - Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
- Surface Electromyography (sEMG)
| 10 weeks | 01 April 2021 | 23 May 2022 | 1 | |
