| NCT02510365 | Functional Neural Regeneration Collagen Scaffold Transplantation in Acute Spinal Cord Injury Patients | Chinese Academy of Sciences | | - Age 18 - 65 yrs
- Level C4-T12
AIS A- ≤ 21 days
| | 20 | PHASE1 | Surgery | General health | - Adverse Events (AEs)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Motor Evoked Potentials (MEPs)
| 12 months | 01 April 2015 | 29 July 2015 | 5 | |
| NCT01485458 | Optimal Treatment for Spinal Cord Injury Associated With Cervical Canal Stenosis (OSCIS) Study | Tokyo University | | - Age 20 - 79 yrs
- Level C5-S5
AIS C- ≤ 48 hours
| Ended | 72 | NA | Surgery | Standing/walking/mobility | - American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Neuropathoc Pain Symptom Inventory (NPSI)
- Short Form 36 (SF-36)
- Spinal Cord Independence Measure (SCIM)
- Walking Index for Spinal Cord Injury (WISCI) and WISCI II
| 1 year | 01 December 2011 | 05 December 2011 | 1 | |
| NCT02688062 | NeuroRegen Scaffold™ With Bone Marrow Mononuclear Cells Transplantation vs. Intradural Decompression and Adhesiolysis in SCI | Chinese Academy of Sciences | | - Age 18 - 60 yrs
- Level T2-T12
AIS A- All
| | 22 | PHASE1, PHASE2 | Biological/cell based | General health | - Adverse Events (AEs)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Bowel and bladder control
- Functional Independence Measure (FIM)
- Magnetic Resonance Imaging (MRI) - conventional/anatomical and quantitative
- Motor Evoked Potentials (MEPs)
- Sensory evoked potentials (including mixed and dermatomal, mSSEPs, dSSEPs, contact heat/laser evoked potentials- CHEPS/LEPs)
| 24 months | 01 January 2016 | 23 February 2016 | 1 | |
| NCT02982811 | Intelligent Activity-based Client-centred Training | PXL University College | Parallel Assignment | - Age ≥ 18 yrs
- Level C1-S5
AIS - ≥ 3 months
| Ended | 47 | Not Applicable | Rehabilitation | Standing/walking/mobility | - Canadian Occupational Performance Measure
- Short Form 36 (SF-36)
| 6 weeks | 01 March 2017 | 05 December 2016 | 4 | |
| NCT05756894 | Neurostimulation for Respiratory Function After Spinal Cord Injury | Shirley Ryan AbilityLab | | - Age 18 - 85 yrs
- Level C1-C5
AIS - ≥ 6 months
- have respiratory deficits requiring ventilator use or demonstrate reduced vital capacity (less than 80%)
- Have a caregiver or family member who is trained and willing to operate the ventilator during study visits
- NOT be completely dependent on the support of a diaphragmatic pacer (24 hours per day)
- NOT have history of head injury or stroke
- NOT have history of seizures or epilepsy
- NOT be taking medications that lower seizure threshold
- NOT have metal in the skull including plates, shrapnel, cochlear implants or aneurysm clips
| Recruiting | 10 | NA | Technology | General health | - Motor Evoked Potentials (MEPs)
| 14 weeks | 28 February 2023 | 07 March 2023 | 1 | |
| NCT05693181 | Cord Blood Cells in Patients With Acute SCI | Sklifosovsky Institute of Emergency Care | | - Age 18 - 75 yrs
- Level C1-L5
AIS A, B- ≤ 7 days
- have had decompressive, stabilizing surgery within 5 days post-SCI and prior to the first cell infusion
- NOT have motor function in lower limbs
| | 80 | PHASE1, PHASE2 | Biological/cell based | General health | - Adverse Events (AEs)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Beck Depression Inventory (BDI)
- Short Form 36 (SF-36)
| 12 months | 05 December 2022 | 20 January 2023 | 2 | |
