| NCT04971408 | Impact of Passive Heat on Metabolic, Inflammatory and Vascular Health in Persons With Spinal Cord Injury | VA Office of Research and Development | | - Age 18 - 60 yrs
- Level C1-S5
AIS A, B, C, D- 1 years - 60 years
| Ended | 10 | NA | Rehabilitation | General health | | | 01 July 2022 | 21 July 2021 | 1 | |
| NCT04041063 | Rehabilitation and Cortical Remodeling After Surgical Intervention for Spinal Cord Injury | Burke Medical Research Institute | | - Age 18 - 50 yrs
- Level C5-C7
AIS A, B, C, D- 6 months - 50 years
- have a C5, C6, or C7 level spinal cord injury for at least 6 months and have some motor dysfunction in the hand.
- have function in the “donor” nerve to be used in the nerve transfer surgery (usually a nerve innervated by a spinal cord segment above the spinal cord injury level).
- have one of the following ASIA impairment scale (AIS):
- AIS A: complete; no feeling or movement below the injury
- AIS B: incomplete; have some feeling, but no movement, below the injury
- AIS C: incomplete; at least some feeling and mostly weak movement below the injury
- AIS D: incomplete; at least some feeling and, some weak but mostly stronger movement below the injury)
- be between the ages of 18 and 50 years
- NOT have a history of seizures, presence of surgically implanted foreign bodies such as a pacemaker, metal plate in the skull, and metal inside the skull.
| Active | 6 | PHASE2 | Technology | Arm/hand function | - Spinal Cord Independence Measure (SCIM)
| | 26 July 2019 | 01 August 2019 | 1 | |
| NCT05095454 | Short-Term Transcutaneous or Epidural Spinal Stimulation for Enabling Motor Function in Humans With SCI | Mayo Clinic | | - Age ≥ 22 yrs
- Level C1-T10
AIS A, B, C, D- ≥ 1 years
- NOT have a history of frequent, severe, autonomic dysreflexia.
- NOT have history of frequent hypotension or frequent hypertension.
- NOT be ventilator dependent
- have intact spinal reflexes below the level of injury
| Ended | 6 | NA | Technology | Standing/walking/mobility | - 6-Minute Walk Test (6MWT)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Electromyography
- Motor evoked potential
- Neurogenic Bladder Symptom Score
- Neurogenic Bowel Dysfunction Score (NBD or NBDS)
- Sensory evoked potentials (including mixed and dermatomal, mSSEPs, dSSEPs, contact heat/laser evoked potentials- CHEPS/LEPs)
- Spinal Cord Injury Spasticity Evaluation Tool (SCI-SET)
| 5 months | 04 March 2022 | 27 October 2021 | 1 | |
| NCT05094362 | Operant Conditioning of Spinal Reflexes Training System--Reflex Operant Down Conditioning | Medical University of South Carolina | | - Age ≥ 18 yrs
- Level C1-T10
AIS B, C, D- ≥ 1 years
- • ability to ambulate at least 10 m with or without an assistive device within 100 seconds
- • have clinical signs of spasticity in the plantarflexor muscles (gas pedal movement).
- • NOT have a pre-existing or confounding neurological condition (e.g., history of Multiple Sclerosis, Traumatic Brain Injury, Stroke, Parkinson's disease)
- • NOT have a cardiac condition.
| Recruiting | 25 | NA | Rehabilitation | Spasticity | - 10 Meter Walking Test (10 MWT)
- 6-Minute Walk Test (6MWT)
- Ashworth and Modified Ashworth Scale (MAS)
- Berg Balance Scale (BBS)
- Functional Independence Measure (FIM)
- H reflex
- Manual Muscle Test (MMT)
- Spinal Cord Independence Measure (SCIM)
- Tardieu Scale
- Walking Index for Spinal Cord Injury (WISCI) and WISCI II
| 3 months | 23 August 2023 | 26 October 2021 | 1 | |
| NCT05094752 | Assessment of the Effects of Early Proprioceptive Stimulations in Patients With Spinal Cord Injury | Assistance Publique - Hôpitaux de Paris | | - Age ≥ 18 yrs
- Level C1-T6
AIS A, B, C, D- ≤ 10 days
| | 40 | NA | Technology | Spasticity | - American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Ashworth and Modified Ashworth Scale (MAS)
- Spinal Cord Assessment Tool for Spastic Reflexes (SCATS)
- Spinal Cord Independence Measure (SCIM)
| 1 year | 20 October 2021 | 26 October 2021 | 1 | |
| NCT05041322 | Improving Ventilatory Capacity in Those With Chronic High Level SCI | Spaulding Rehabilitation Hospital | | - Age 18 - 50 yrs
- Level C1-T3
AIS A, B, C- ≥ 24 months
- able to perform arm crank exercise
- NOT have a heart disease (cardiomyopathy)
- NOT have high blood pressure (>140/90 mmHg or you are taking high blood pressure medication)
- NOT have an intrathecal baclofen pump implanted
- NOT regularly use tobacco
| Ended | 13 | PHASE2 | Drug | General health | | 14 days | 29 November 2020 | 13 September 2021 | 1 | |
