| NCT06130449 | Testosterone and Neural Function in Men With Spinal Cord Injury | VA Office of Research and Development | | - Age 18 - 80 yrs
- Level C1-S5
AIS A, B, C, D- ≥ 12 months
- NOT have ventilator dependence or patent tracheostomy site
- NOT have implanted devices with electromagnetic properties
- NOT have a hitsory of other neurologic disorders or head trauma
- NOT have brain injury, stroke, tumor, multiple sclerosis, or abscess
| Recruiting | 15 | EARLY_PHASE1 | Drug | General health | - Blood Pressure and Heart Rate Regulation
- Electromyography
| 1 day | 01 April 2024 | 14 November 2023 | 2 | |
| NCT01621113 | Combination Therapy With Dalfampridine and Locomotor Training for Chronic, Motor Incomplete Spinal Cord Injury | Kessler Foundation | | - Age 18 - 70 yrs
- Level -
AIS - All
| Ended | 27 | PHASE2 | | | | | 01 June 2012 | 18 June 2012 | 1 | |
| NCT04631471 | Regeneration in Cervical Degenerative Myelopathy | Cambridge University Hospitals NHS Foundation Trust | Parallel Assignment | - Age 18 - 80 yrs
- Level C1-S5
AIS A, B, C, D- ≤ 80 years
- have a cervical degenerative myelopathy (spinal cord compression with neurological impairment because of degenerative disease of the cervical spine)
- have a preoperative modified Japanese Orthopedic Association (mJOA) score ≥8 and ≤14 (consistent with moderate to severe neurological impairment)
- not have had previous surgical decompression of the cervical spine
| Recruiting | 400 | Phase 3 | Surgery | Arm/hand function | | | 22 December 2021 | 17 November 2020 | 1 | |
| NCT05638191 | Nerve Transfer Surgery to Restore Upper-limb Function After Cervical Spinal Cord Injury | University of British Columbia | | - Age 18 - 70 yrs
- Level C5-C8
AIS A, B- 6 months - 9 months
| Recruiting | 40 | | Surgery | Arm/hand function | - Ashworth and Modified Ashworth Scale (MAS)
- Beck Depression Inventory (BDI)
- Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
- Spinal Cord Independence Measure (SCIM)
| 2 years | 03 June 2021 | 06 December 2022 | 4 | |
| NCT04276181 | Combined Nerve and Tendon Transfer for the Restoration of Hand Function in Individuals With Tetraplegia | Göteborg University | | - Age 15 - 55 yrs
- Level C5-C7
AIS A, B, C, D- ≤ 12 months
- meet criteria for nerve transfer surgery
| Recruiting | 94 | | Surgery | Arm/hand function | | | 26 January 2020 | 19 February 2020 | 1 | |
| NCT04023591 | Nerve Transfer After Spinal Cord Injury- Multi-center | Washington University School of Medicine | | - Age 18 - 65 yrs
- Level C4-C8
AIS A, B- ≤ 36 months
- have a spinal cord injury for less than 36 months.
- have a neurological level of injury between C4-C8
- have one of the following ASIA impairment scale (AIS):
- AIS A: complete; no feeling or movement below the injury
- AIS B: incomplete; have some feeling, but no movement, below the injury
- Stable ASIA scores with no evidence of functional improvement in motor or sensory examination for at least 3 months.
- pass criteria assessing the viability of the target (paralyzed) muscle and the donor nerve
- be between the ages of 18-65 years.
- have undergone at least 3 months of non-operative rehab therapy.
| Active | 70 | | Surgery | Arm/hand function | | | 13 April 2020 | 17 July 2019 | 13 | |
