This phase I trial is enrolling 17 participants with chronic cervical spinal cord injury to test the effect of paired corticospinal-motor neuronal stimulation (PCMS) combined with exercise on arm and hand function. PCMS involves the simultaneous or paired delivery of transcranial magnetic stimulation (TMS) to the brain and peripheral nerve stimulation (PNS) to the muscles. TMS is a non-invasive technique which uses a magnetic field to stimulate the brain. PNS is a non-invasive technique that uses electrical impulses to stimulate the nerves. Investigators want to see if motor skills acquired in one limb can transfer to the opposite, untrained limb. If included, participants will receive the following interventions in a random order: PCMS alone; PCMS combined with exercise on the opposite limb; and a sham stimulation combined with exercise on the opposite limb. Final testing of arm and hand function will be performed 4-6 hours after the session.
Type
Details
- Participants will receive the following interventions in a random order: PCMS alone, PCMS combined with exercise on the opposite limb, and a sham stimulation combined with exercise on the opposite limb. - Paired corticospinal-motor neuronal stimulation (PCMS) involves the simultaneous or paired delivery of transcranial magnetic stimulation (TMS) to the brain and peripheral nerve stimulation (PNS) to the muscles. - TMS is a non-invasive technique which uses a magnetic field to stimulate the brain. A coil (held over the head) delivers the magnetic stimulation that activates the central nervous system. - PNS is a non-invasive technique that uses electrical impulses to stimulate the nerves. Electrodes (placed on the skin) deliver the stimulation that activates the peripheral nervous system. - Final testing of arm and hand function will be performed 4-6 hours after the session.
Main benefits
General health
Additional benefits
Arm/hand function
Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn moreWings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more