About this trial

This trial is enrolling 22 individuals with spasticity associated with spinal cord injury, stroke, and cerebral palsy to test the effect of a procedure called stereotactic radiosurgery dorsal rhizotomy. It uses a precisely focused form of radiation therapy delivered in a single session to the sensory nerve roots in the back with the intent of reducing the function of nerves that contribute to spasticity. Similar to radiation therapy used to treat tumors, this intervention is delivered to the treatment area from outside of the body, with specific targeting and dosing appropriate for this neurological application. If included, participants will receive either the active intervention or a sham (fake) intervention. Final testing of spasticity and quality of life will be performed after 2 years. Participants who receive the sham treatment will be eligible to receive the active intervention after 6 months.