This trial is enrolling 25 individuals with chronic cervical/thoracic spinal cord injury for 2 studies on blood pressure. Study 1 will test the effect of midodrine and droxidopa on blood pressure in seated or supine positions. Study 2 compares the use of a compression garment, midodrine, and droxidopa against placebo on blood pressure and other symptoms of blood pressure changes. If included, participants will visit the laboratory on 6 occasions to receive increasing doses of midodrine or droxidopa (study 1). For study 2, the use of compression garments, midropine, or droxidopa will be compared to placebo to assess the effect on blood pressure control, autonomic dysreflexia, orthostatic hypotension, fatigue and thermal comfort. Final assessments will be performed after 3 years.
Traumatic
Type
Details
- Study 1: participants will undergo six sessions where they will receive sequentially increasing doses of midodrine and droxidopa to test the effect on blood pressure in different positions (supine and seated). - Study 2: participants will receive a compression garment, midodrine, droxidopa, or placebo drug to test the effect on blood pressure and other symptoms resulting from changes in blood pressure. - Final testing of blood pressure control, autonomic dysreflexia, orthostatic hypotension, fatigue and thermal comfort will be performed after 3 years.
Main benefits
General health
Additional benefits
Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn moreWings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more