This trial is enrolling individuals spinal cord injuries for at least 4 weeks to test the effect a drug (Dalfampridine, 4-AP) in combination with spike timing dependent plasticity (STDP) stimulation and lower limb training on walking and other aspects of spinal cord function, including electrical measures of nerve conduction. STDP is a technique that applies paired electrical stimulation to the spinal cord and peripheral nerves. If included, participants will receive either: 1) 4-AP + STDP + training for 10 sessions; or 2) a placebo drug + STDP + training for 10 session. Following these sessions, participants in either arm of the study may be eligible for inclusion in an additional period of treatment with 4-AP + STDP + training for 40 sessions.
Type
Details
Participants will receive either 1) the active drug (Dalfampridine) + STDP + training for 10 sessions, 2) the placebo drug + STDP + training for 10 session. They will then undergo a number of functional and electrical tests that will involve stimulation with electrodes on the skin. They may also be eligible for an additional period of treatment with the active drug + STDP + training for 40 sessions.
Main benefits
Standing/walking/mobility
Additional benefits
Bowel health
Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn moreWings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more