This is a trial enrolling individuals with spinal cord injuries to test the effect of resistance training combined with spinal cord stimulation on walking function. Spinal cord stimulation is a technique for stimulating the spinal cord to modify spinal cord function. In this trial, electrodes are surgically implanted next to the spinal cord. The training program includes walking exercises in a powered wearable robotic device (exoskeleton). The study targets the additional effects of lower limb resistance training on exoskeleton-assisted walking with spinal cord stimulation. If included, individuals will randomly be assigned to one of two study groups: a) either performing the study program of exoskeleton-assisted walking with spinal cord stimulation added after 6 months; or b) performing the study program of exoskeleton-assisted walking with spinal cord stimulation along with additional resistance training of the lower extremities. Final testing will be performed after 12 months.
Traumatic
Type
Details
- ES (Epidural Stimulation)= electrodes are surgically implanted next to the spinal cord - EAW=Exoskeleton-assisted walking - RT= Resistance training of the lower extremities - Outcome measures throughout the study duration -EAW+ES+RT (experimental group): EAW+ES (3x/week) for 6 months followed by another 6 months of EAW+ES (3x/wk) and progressive RT 2x/week. EAW+delayed-ES+no-RT (control group): EAW 3x/week (without RT) for 6 months followed by another 6 months of EAW+ES and passive movement/stretching 2x/week.
Main benefits
Standing/walking/mobility
Additional benefits
General health
Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn moreWings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more