This is a clinical trial enrolling individuals with incomplete spinal cord injuries to study spasticity. Spasticity is common in SCI, ranging from mild stiffness or tightening of muscles to uncontrollable muscle contractions. One of the goals of this study is to better understand the specific spinal cord nerve pathways responsible for spasticity. Transcranial magnetic stimulation and magnetic resonance imaging (MRI) will be used to measure activity of spinal cord nerves. Participants will undergo 2-3 study visits with muscle and nerve testing and MRI. These imaging studies will be associated with clinical measures of spasticity, combining exercise training with an acoustic (sound) startle stimulus on arm and leg function. The goal is to improve arm and leg muscle recovery by enhancing control over spinal cord nerve networks. Participants do not have to have spasticity to participate in this study.
Traumatic
Type
Details
2-3 study visits within a time span of a month Participation in muscle testing (upper and lower limb), nerve testing and magnetic resonance imaging (MRI) Participation in exercise training (with or without sounds delivered through headphones)
Main benefits
Spasticity
Additional benefits
Arm/hand function
General health
Standing/walking/mobility
Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn moreWings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more