This trial is recruiting individuals with chronic spinal cord injuries to study whether implanted stem cells derived from human umbilical cord tissue or umbilical cord blood (hUC-MSCs or hUCB-MSCs) are safe using various forms of injection. The trial will also determine whether the stem cells change locomotor (walking) function and/or muscle tension. Participants will be randomly assigned to one of seven groups. One arm is a control group that receives a placebo injection; the other six arms vary the placement of stem cell injections (e.g., into the blood stream, into the injury area, etc.) All participants will also receive standard rehabilitative care. After 1, 3, 6, and 12 months, each participant will be evaluated in terms of safety and changes in function.
Traumatic
Type
Details
The participant will receive either 1) intravenous injections of hUC-MSCs/hUCB-MSCs, 2) hUC-MSCs/hUCB-MSCs injections into the fluid around the lower spinal cord, 3) hUC-MSCs/ hUCB-MSCs into the injured area of the spinal cord, or 4) a control intravenous injection of saline as a placebo control. After 1, 3, 6, and 12 months, the participant will be evaluated in terms of safety and potential efficacy of the cell transplantation.
Main benefits
Standing/walking/mobility
Additional benefits
Arm/hand function
General health
Pain
Sensory function
Spasticity
Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn moreWings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more