This is a trial to test the effect of a technique for stimulating the spinal cord with an implanted electrode placed next to the spinal cord (spinal cord epidural stimulation: scES) on standing and stepping function after spinal cord injury. If included, the participant will have an invasive procedure to place the scES stimulating electrode into the spinal canal. The participant will undergo 80 sessions stand and step training without scES. Then they will undergo 80 sessions with specific scES settings while practicing standing (stand-scES), stepping (step-scES), and voluntary movements of the legs and trunk (vol-scES). All training will also be performed with assistance of a trainer overground or in a harness on a body weight support treadmill. Stepping, standing, voluntary movement, cardiovascular, respiratory, bladder, bowel, and sexual function will be tested after 1 year.
Traumatic
Type
Details
Surgical implantation of scES stimulation device with epidural electrodes 80 sessions of stand and step training without scES. 80 sessions of scES while practicing standing (stand-scES), stepping (step-scES), and voluntary movements of the legs and trunk (vol-scES). All training will also be performed with assistance of a trainer overground or in a harness on a body weight support treadmill. Stepping, standing, voluntary movement, cardiovascular, respiratory, bladder, bowel, and sexual function will be tested after 1 year.
Main benefits
Standing/walking/mobility
Additional benefits
Bladder health/function
Bowel health
General health
Sexual health
Mechanism of action
Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn moreWings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more