This trial is recruiting individuals with chronic, complete spinal cord injuries to assess the effect of transplanting a type of stem cell (cells that can turn into different cell types). This study uses cells from the umbilical cord (umbilical cord blood mononuclear stem cells; UCBMSC). The cells will be surgically transplanted into the spinal cord. After the transplant, the study also adds lithium carbonate (Li2CO3) taken by mouth for 6 weeks, followed by intensive stepping (locomotor) training for 3-6 months (up to 6 hours per day, 6 days per week). If included in the study, participants will be randomly assigned to one of the three study groups: walking training only; walking training + UCBMSC transplantation + placebo; or walking training + UCBMSC transplantation + lithium carbonate. All participants will receive 3-6 months of intensive locomotor training and will be assessed for walking ability, other activities of daily living, and overall sensory and motor function over 48 weeks.
Traumatic
Type
Details
Surgery for the transplantation of the stem cells into the spinal cord 6 weeks of lithium carbonate intake 3-6 months intensive locomotor training: Up to 6 hours a day, 6 days a week
Main benefits
Standing/walking/mobility
Additional benefits
Arm/hand function
General health
Pain
Sensory function
Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn moreWings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more