About this trial

This trial is recruiting individuals with chronic incomplete cervical (neck area) spinal cord injuries to test the safety and possible effect of acute intermittent hypoxia (AIH) in combination with arm and hand training. AIH is a procedure wherein the oxygen levels of breathed air are reduced for a short duration (less than 2 min), alternated by exposure to room air with normal oxygen levels. Previous studies have shown that AIH is safe and effective; a recent study showed that coupling AIH with overground gait (walking) training increased walking endurance and walking speed. If selected for the trial, participants will be assigned to one of four groups: 1) AIH treatment with upper extremity training (using the Armeo Spring device, a gravity support system based on an ergonomic arm exoskeleton with integrated springs); 2) AIH treatment without upper extremity training; 3) sham AIH with upper extremity Armeo training; 4) sham AIH without upper extremity training. Participants will not know about their level of oxygen, which is provided via mask. Sham AIH uses room air. The latter three groups will serve as controls for the AIH treatment with upper extremity training. This study will measure changes in upper extremity function, dexterity, and ability to complete activities of daily living.