This trial is recruiting individuals with incomplete spinal cord injuries to test the effect of breathing air with low oxygen (acute intermittent hypoxia) in combination with caffeine to improve leg function. Participants will swallow capsules containing either caffeine or sugar (placebo). Each will receive both caffeine and sugar capsules, but the order of the capsules will not be known. After 1 hour participants will breathe short periods of low oxygen air through a face mask, alternating with room air. Following the breathing session, saliva will be tested for the amount of caffeine in the body. After each treatment (caffeine or placebo), walking speed and leg strength will be assessed
Ischemia
Traumatic
Non-traumatic
Type
Details
The participant will take a capsule containing caffeine for one interventional session, and sugar (placebo) for the second session. After 1 hour, the participant will breathe air with low oxygen through a face mask. The participant will be asked to spit into a small container before and after each breathing session. The participant will be tested for walking speed and leg strength after each session.
Main benefits
Standing/walking/mobility
Additional benefits
General health
Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn moreWings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more